• Contreras L, Drago I, Zampese E, Pozzan T (2010) Mitochondria: The calcium connection. Biochim. Biophys. Acta 1797:607-18. PubMed
  • Ferrari D, Pinton P, Campanella M, Callegari MG, Pizzirani C, Rimessi A, Di Virgilio F, Pozzan T, Rizzuto R (2010) Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation. Biochem. Biophys. Res. Commun. 391:575-81. PubMed
  • Röder IV, Choi KR, Reischl M, Petersen Y, Diefenbacher ME, Zaccolo M, Pozzan T, Rudolf R (2010) Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo. Proc. Natl. Acad. Sci. U.S.A. 107:2031-6. PubMed
  • Gómez-Gonzalo M, Losi G, Chiavegato A, Zonta M, Cammarota M, Brondi M, Vetri F, Uva L, Pozzan T, de Curtis M, Ratto GM, Carmignoto G (2010) An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol. 8:e1000352. PubMed
  • Giacomello M, Drago I, Bortolozzi M, Scorzeto M, Gianelle A, Pizzo P, Pozzan T (2010) Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels. Mol. Cell 38:280-90. PubMed
  • De Palma C, Falcone S, Pisoni S, Cipolat S, Panzeri C, Pambianco S, Pisconti A, Allevi R, Bassi MT, Cossu G, Pozzan T, Moncada S, Scorrano L, Brunelli S, Clementi E (2010) Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation. Cell Death Differ. 17:1684-96. PubMed
  • Lissandron V, Podini P, Pizzo P, Pozzan T (2010) Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment Proc. Natl. Acad. Sci. U.S.A. 107:9198-203. PubMed
  • Costa A, Drago I, Behera S, Zottini M, Pizzo P, Schroeder JI, Pozzan T, Schiavo FL (2010) H2O2 in plant peroxisomes: an in vivo analysis uncovers a Ca(2+)-dependent scavenging system. Plant J. 62:760-72. PubMed
  • Wiederkehr A, Park KS, Dupont O, Demaurex N, Pozzan T, Cline GW, Wollheim CB (2009) Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation. EMBO J. 28:417-28. PubMed
  • Maritan M, Monaco G, Zamparo I, Zaccolo M, Pozzan T, Lodovichi C (2009) Odorant receptors at the growth cone are coupled to localized cAMP and Ca2+ increases. Proc. Natl. Acad. Sci. U.S.A. 106:3537-42. PubMed

  • Contreras L, Drago I, Zampese E, Pozzan T (2010) Mitochondria: The calcium connection. Biochim. Biophys. Acta 1797:607-18. PubMed
  • Ferrari D, Pinton P, Campanella M, Callegari MG, Pizzirani C, Rimessi A, Di Virgilio F, Pozzan T, Rizzuto R (2010) Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation. Biochem. Biophys. Res. Commun. 391:575-81. PubMed
  • Röder IV, Choi KR, Reischl M, Petersen Y, Diefenbacher ME, Zaccolo M, Pozzan T, Rudolf R (2010) Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo. Proc. Natl. Acad. Sci. U.S.A. 107:2031-6. PubMed
  • Gómez-Gonzalo M, Losi G, Chiavegato A, Zonta M, Cammarota M, Brondi M, Vetri F, Uva L, Pozzan T, de Curtis M, Ratto GM, Carmignoto G (2010) An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol. 8:e1000352. PubMed
  • Giacomello M, Drago I, Bortolozzi M, Scorzeto M, Gianelle A, Pizzo P, Pozzan T (2010) Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels. Mol. Cell 38:280-90. PubMed
  • De Palma C, Falcone S, Pisoni S, Cipolat S, Panzeri C, Pambianco S, Pisconti A, Allevi R, Bassi MT, Cossu G, Pozzan T, Moncada S, Scorrano L, Brunelli S, Clementi E (2010) Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation. Cell Death Differ. 17:1684-96. PubMed
  • Lissandron V, Podini P, Pizzo P, Pozzan T (2010) Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment Proc. Natl. Acad. Sci. U.S.A. 107:9198-203. PubMed
  • Costa A, Drago I, Behera S, Zottini M, Pizzo P, Schroeder JI, Pozzan T, Schiavo FL (2010) H2O2 in plant peroxisomes: an in vivo analysis uncovers a Ca(2+)-dependent scavenging system. Plant J. 62:760-72. PubMed
  • Wiederkehr A, Park KS, Dupont O, Demaurex N, Pozzan T, Cline GW, Wollheim CB (2009) Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation. EMBO J. 28:417-28. PubMed
  • Maritan M, Monaco G, Zamparo I, Zaccolo M, Pozzan T, Lodovichi C (2009) Odorant receptors at the growth cone are coupled to localized cAMP and Ca2+ increases. Proc. Natl. Acad. Sci. U.S.A. 106:3537-42. PubMed
  • Cintra-Francischinelli M, Pizzo P, Rodrigues-Simioni L, Ponce-Soto LA, Rossetto O, Lomonte B, Gutiérrez JM, Pozzan T, Montecucco C (2009) Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors. Cell. Mol. Life Sci. 66:1718-28. PubMed
  • Baumgartner HK, Gerasimenko JV, Thorne C, Ferdek P, Pozzan T, Tepikin AV, Petersen OH, Sutton R, Watson AJ, Gerasimenko OV (2009) Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. J. Biol. Chem. 284:20796-803. PubMed
  • Brunello L, Zampese E, Florean C, Pozzan T, Pizzo P, Fasolato C (2009) Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake. J. Cell. Mol. Med. 13:3358-69. PubMed
  • Pozzan T, Rudolf R (2009) Measurements of mitochondrial calcium in vivo. Biochim. Biophys. Acta 1787:1317-23. PubMed
  • Pontarin G, Fijolek A, Pizzo P, Ferraro P, Rampazzo C, Pozzan T, Thelander L, Reichard PA, Bianchi V (2008) Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage. Proc. Natl. Acad. Sci. U.S.A. 105:17801-6. PubMed
  • Contento RL, Molon B, Boularan C, Pozzan T, Manes S, Marullo S, Viola A (2008) CXCR4-CCR5: a couple modulating T cell functions. Proc. Natl. Acad. Sci. U.S.A. 105:10101-6. PubMed
  • Drago I, Giacomello M, Pizzo P, Pozzan T (2008) Calcium dynamics in the peroxisomal lumen of living cells. J. Biol. Chem. 283:14384-90. PubMed
  • Colella M, Pozzan T (2008) Cardiac cell hypertrophy in vitro: role of calcineurin/NFAT as Ca2+ signal integrators. Ann. N. Y. Acad. Sci. 1123:64-8. PubMed
  • Colella M, Grisan F, Robert V, Turner JD, Thomas AP, Pozzan T (2008) Ca2+ oscillation frequency decoding in cardiac cell hypertrophy: role of calcineurin/NFAT as Ca2+ signal integrators. Proc. Natl. Acad. Sci. U.S.A. 105:2859-64. PubMed
  • Aguiari P, Leo S, Zavan B, Vindigni V, Rimessi A, Bianchi K, Franzin C, Cortivo R, Rossato M, Vettor R, Abatangelo G, Pozzan T, Pinton P, Rizzuto R (2008) High glucose induces adipogenic differentiation of muscle-derived stem cells. Proc. Natl. Acad. Sci. U.S.A. 105:1226-31. PubMed

  • Pizzo P, Pozzan T (2007) Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics. Trends Cell Biol. 17:511-7. PubMed
  • Giacomello M, Drago I, Pizzo P, Pozzan T (2007) Mitochondrial Ca2+ as a key regulator of cell life and death. Cell Death Differ. 14:1267-74. PubMed
  • Rigoni M, Pizzo P, Schiavo G, Weston AE, Zatti G, Caccin P, Rossetto O, Pozzan T, Montecucco C (2007) Calcium influx and mitochondrial alterations at synapses exposed to snake neurotoxins or their phospholipid hydrolysis products. J. Biol. Chem. 282:11238-45. PubMed
  • Rizzuto R, Pozzan T (2006) Microdomains of intracellular Ca2+: molecular determinants and functional consequences. Physiol. Rev. 86:369-408. PubMed
  • Crippa D, Schenk U, Francolini M, Rosa P, Verderio C, Zonta M, Pozzan T, Matteoli M, Carmignoto G (2006) Synaptobrevin2-expressing vesicles in rat astrocytes: insights into molecular characterization, dynamics and exocytosis. J. Physiol. (Lond.) 570:567-82. PubMed
  • Mongillo M, Tocchetti CG, Terrin A, Lissandron V, Cheung YF, Dostmann WR, Pozzan T, Kass DA, Paolocci N, Houslay MD, Zaccolo M (2006) Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway. Circ. Res. 98:226-34. PubMed
  • Fellin T, Pozzan T, Carmignoto G (2006) Purinergic receptors mediate two distinct glutamate release pathways in hippocampal astrocytes. J. Biol. Chem. 281:4274-84. PubMed
  • Rudolf R, Magalhães PJ, Pozzan T (2006) Direct in vivo monitoring of sarcoplasmic reticulum Ca2+ and cytosolic cAMP dynamics in mouse skeletal muscle. J. Cell Biol. 173:187-93. PubMed
  • Beltramello M, Piazza V, Bukauskas FF, Pozzan T, Mammano F (2005) Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness. Nat. Cell Biol. 7:63-9. PubMed
  • Oakes SA, Scorrano L, Opferman JT, Bassik MC, Nishino M, Pozzan T, Korsmeyer SJ (2005) Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 102:105-10. PubMed
  • Filippin L, Abad MC, Gastaldello S, Magalhães PJ, Sandonà D, Pozzan T (2005) Improved strategies for the delivery of GFP-based Ca2+ sensors into the mitochondrial matrix. Cell Calcium 37:129-36. PubMed
  • Giacomello M, Barbiero L, Zatti G, Squitti R, Binetti G, Pozzan T, Fasolato C, Ghidoni R, Pizzo P (2005) Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia. Neurobiol. Dis. 18:638-48. PubMed
  • Spirlì C, Fiorotto R, Song L, Santos-Sacchi J, Okolicsanyi L, Masier S, Rocchi L, Vairetti MP, De Bernard M, Melero S, Pozzan T, Strazzabosco M (2005) Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a cystic fibrosis transmembrane conductance regulator-independent mechanism. Gastroenterology 129:220-33. PubMed
  • Warrier S, Belevych AE, Ruse M, Eckert RL, Zaccolo M, Pozzan T, Harvey RD (2005) Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor. Am. J. Physiol., Cell Physiol. 289:C455-61. PubMed
  • Gerbino A, Ruder WC, Curci S, Pozzan T, Zaccolo M, Hofer AM (2005) Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations. J. Cell Biol. 171:303-12. PubMed
  • Rizzuto R, Duchen MR, Pozzan T (2004) Flirting in little space: the ER/mitochondria Ca2+ liaison. Sci. STKE 2004:re1. PubMed
  • Zatti G, Ghidoni R, Barbiero L, Binetti G, Pozzan T, Fasolato C, Pizzo P (2004) The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores. Neurobiol. Dis. 15:269-78. PubMed
  • Bassik MC, Scorrano L, Oakes SA, Pozzan T, Korsmeyer SJ (2004) Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J. 23:1207-16. PubMed
  • Abad MF, Di Benedetto G, Magalhães PJ, Filippin L, Pozzan T (2004) Mitochondrial pH monitored by a new engineered green fluorescent protein mutant. J. Biol. Chem. 279:11521-9. PubMed
  • Mongillo M, McSorley T, Evellin S, Sood A, Lissandron V, Terrin A, Huston E, Hannawacker A, Lohse MJ, Pozzan T, Houslay MD, Zaccolo M (2004) Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ. Res. 95:67-75. PubMed
  • Gri G, Molon B, Manes S, Pozzan T, Viola A (2004) The inner side of T cell lipid rafts. Immunol. Lett. 94:247-52. PubMed
  • Rudolf R, Mongillo M, Magalhães PJ, Pozzan T (2004) In vivo monitoring of Ca(2+) uptake into mitochondria of mouse skeletal muscle during contraction. J. Cell Biol. 166:527-36. PubMed
  • Fellin T, Pascual O, Gobbo S, Pozzan T, Haydon PG, Carmignoto G (2004) Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. Neuron 43:729-43. PubMed
  • Burgo A, Carmignoto G, Pizzo P, Pozzan T, Fasolato C (2003) Paradoxical Ca2+ rises induced by low external Ca2+ in rat hippocampal neurones. J. Physiol. (Lond.) 549:537-52. PubMed
  • Rizzuto R, Pozzan T (2003) When calcium goes wrong: genetic alterations of a ubiquitous signaling route. Nat. Genet. 34:135-41. PubMed
  • Gazarini ML, Thomas AP, Pozzan T, Garcia CR (2003) Calcium signaling in a low calcium environment: how the intracellular malaria parasite solves the problem. J. Cell Biol. 161:103-10. PubMed
  • Scorrano L, Oakes SA, Opferman JT, Cheng EH, Sorcinelli MD, Pozzan T, Korsmeyer SJ (2003) BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science 300:135-9. PubMed
  • Zaccolo M, Pozzan T (2003) CAMP and Ca2+ interplay: a matter of oscillation patterns. Trends Neurosci. 26:53-5. PubMed
  • Pozzan T, Mongillo M, Rudolf R (2003) The Theodore Bücher lecture. Investigating signal transduction with genetically encoded fluorescent probes. Eur. J. Biochem. 270:2343-52. PubMed
  • Rudolf R, Mongillo M, Rizzuto R, Pozzan T (2003) Looking forward to seeing calcium. Nat. Rev. Mol. Cell Biol. 4:579-86. PubMed
  • Aronchik I, Behne MJ, Leypoldt L, Crumrine D, Epstein E, Ikeda S, Mizoguchi M, Bench G, Pozzan T, Mauro T (2003) Actin reorganization is abnormal and cellular ATP is decreased in Hailey-Hailey keratinocytes. J. Invest. Dermatol. 121:681-7. PubMed
  • Behne MJ, Tu CL, Aronchik I, Epstein E, Bench G, Bikle DD, Pozzan T, Mauro TM (2003) Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores. J. Invest. Dermatol. 121:688-94. PubMed
  • Filippin L, Magalhães PJ, Di Benedetto G, Colella M, Pozzan T (2003) Stable interactions between mitochondria and endoplasmic reticulum allow rapid accumulation of calcium in a subpopulation of mitochondria. J. Biol. Chem. 278:39224-34. PubMed
  • Oakes SA, Opferman JT, Pozzan T, Korsmeyer SJ, Scorrano L (2003) Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members. Biochem. Pharmacol. 66:1335-40. PubMed
  • Rizzuto R, Pinton P, Ferrari D, Chami M, Szabadkai G, Magalhães PJ, Di Virgilio F, Pozzan T (2003) Calcium and apoptosis: facts and hypotheses. Oncogene 22:8619-27. PubMed
  • Zonta M, Sebelin A, Gobbo S, Fellin T, Pozzan T, Carmignoto G (2003) Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes. J. Physiol. (Lond.) 553:407-14. PubMed
  • Zonta M, Angulo MC, Gobbo S, Rosengarten B, Hossmann KA, Pozzan T, Carmignoto G (2003) Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat. Neurosci. 6:43-50. PubMed

  • Pizzo P, Giurisato E, Tassi M, Benedetti A, Pozzan T, Viola A (2002) Lipid rafts and T cell receptor signaling: a critical re-evaluation. Eur. J. Immunol. 32:3082-91. PubMed
  • Pinton P, Tsuboi T, Ainscow EK, Pozzan T, Rizzuto R, Rutter GA (2002) Dynamics of glucose-induced membrane recruitment of protein kinase C beta II in living pancreatic islet beta-cells. J. Biol. Chem. 277:37702-10. PubMed
  • Rizzuto R, Pozzan T, Carafoli E (2002) Ca2+ on the move: ways and means to translate a multifarious signal. Trends Pharmacol. Sci. 23:348-50. PubMed
  • Zaccolo M, Magalhães P, Pozzan T (2002) Compartmentalisation of cAMP and Ca(2+) signals. Curr. Opin. Cell Biol. 14:160-6. PubMed
  • Zaccolo M, Pozzan T (2002) Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science 295:1711-5. PubMed
  • Zaccolo M, Filippin L, Magalhães P, Pozzan T (2001) Heterogeneity of second messenger levels in living cells. Novartis Found. Symp. 239:85-93; discussion 93. PubMed
  • Pasti L, Zonta M, Pozzan T, Vicini S, Carmignoto G (2001) Cytosolic calcium oscillations in astrocytes may regulate exocytotic release of glutamate. J. Neurosci. 21:477-84. PubMed
  • Robert V, Massimino ML, Tosello V, Marsault R, Cantini M, Sorrentino V, Pozzan T (2001) Alteration in calcium handling at the subcellular level in mdx myotubes. J. Biol. Chem. 276:4647-51. PubMed
  • Pinton P, Ferrari D, Rapizzi E, Di Virgilio F, Pozzan T, Rizzuto R (2001) The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J. 20:2690-701. PubMed
  • Robert V, Gurlini P, Tosello V, Nagai T, Miyawaki A, Di Lisa F, Pozzan T (2001) Beat-to-beat oscillations of mitochondrial [Ca2+] in cardiac cells. EMBO J. 20:4998-5007. PubMed
  • Pizzo P, Burgo A, Pozzan T, Fasolato C (2001) Role of capacitative calcium entry on glutamate-induced calcium influx in type-I rat cortical astrocytes. J. Neurochem. 79:98-109. PubMed
  • Mitchell KJ, Pinton P, Varadi A, Tacchetti C, Ainscow EK, Pozzan T, Rizzuto R, Rutter GA (2001) Dense core secretory vesicles revealed as a dynamic Ca(2+) store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera. J. Cell Biol. 155:41-51. PubMed
  • Bastianutto C, Bestard JA, Lahnakoski K, Broere D, De Visser M, Zaccolo M, Pozzan T, Ferlini A, Muntoni F, Patarnello T, Klamut HJ (2001) Dystrophin muscle enhancer 1 is implicated in the activation of non-muscle isoforms in the skeletal muscle of patients with X-linked dilated cardiomyopathy. Hum. Mol. Genet. 10:2627-35. PubMed
  • Zaccolo M, De Giorgi F, Cho CY, Feng L, Knapp T, Negulescu PA, Taylor SS, Tsien RY, Pozzan T (2000) A genetically encoded, fluorescent indicator for cyclic AMP in living cells Nat. Cell Biol. 2:25-9. PubMed
  • Robert V, Pinton P, Tosello V, Rizzuto R, Pozzan T (2000) Recombinant aequorin as tool for monitoring calcium concentration in subcellular compartments. Meth. Enzymol. 327:440-56. PubMed
  • Pozzan T, Rizzuto R (2000) High tide of calcium in mitochondria. Nat. Cell Biol. 2:E25-7. PubMed
  • Pinton P, Ferrari D, Magalhães P, Schulze-Osthoff K, Di Virgilio F, Pozzan T, Rizzuto R (2000) Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells. J. Cell Biol. 148:857-62. PubMed
  • Zaccolo M, Pozzan T (2000) Imaging signal transduction in living cells with GFP-based probes. IUBMB Life 49:375-9. PubMed
  • Hotta CT, Gazarini ML, Beraldo FH, Varotti FP, Lopes C, Markus RP, Pozzan T, Garcia CR (2000) Calcium-dependent modulation by melatonin of the circadian rhythm in malarial parasites. Nat. Cell Biol. 2:466-8. PubMed
  • Pozzan T, Rizzuto R (2000) The renaissance of mitochondrial calcium transport. Eur. J. Biochem. 267:5269-73. PubMed
  • Rizzuto R, Bernardi P, Pozzan T (2000) Mitochondria as all-round players of the calcium game. J. Physiol. (Lond.) 529 Pt 1:37-47. PubMed
  • De Giorgi F, Ahmed Z, Bastianutto C, Brini M, Jouaville LS, Marsault R, Murgia M, Pinton P, Pozzan T, Rizzuto R (1999) Targeting GFP to organelles. Methods Cell Biol. 58:75-85. PubMed
  • Maechler P, Kennedy ED, Sebö E, Valeva A, Pozzan T, Wollheim CB (1999) Secretagogues modulate the calcium concentration in the endoplasmic reticulum of insulin-secreting cells. Studies in aequorin-expressing intact and permeabilized ins-1 cells. J. Biol. Chem. 274:12583-92. PubMed
  • Pasti L, Carmignoto G, Pozzan T, Battini R, Ferrari S, Lally G, Emson PC (1999) Cellular calcium handling in brain slices from calbindin D28k-deficient mice. Neuroreport 10:2367-72. PubMed
  • Strayle J, Pozzan T, Rudolph HK (1999) Steady-state free Ca(2+) in the yeast endoplasmic reticulum reaches only 10 microM and is mainly controlled by the secretory pathway pump pmr1. EMBO J. 18:4733-43. PubMed
  • Brini M, Pinton P, Pozzan T, Rizzuto R (1999) Targeted recombinant aequorins: tools for monitoring [Ca2+] in the various compartments of a living cell. Microsc. Res. Tech. 46:380-9. PubMed
  • Rizzuto R, Pinton P, Brini M, Chiesa A, Filippin L, Pozzan T (1999) Mitochondria as biosensors of calcium microdomains. Cell Calcium 26:193-9. PubMed
  • Fasolato C, Pizzo P, Pozzan T (1998) Delayed activation of the store-operated calcium current induced by calreticulin overexpression in RBL-1 cells. Mol. Biol. Cell 9:1513-22. PubMed
  • Hofer AM, Landolfi B, Debellis L, Pozzan T, Curci S (1998) Free [Ca2+] dynamics measured in agonist-sensitive stores of single living intact cells: a new look at the refilling process. EMBO J. 17:1986-95. PubMed
  • Hofer AM, Fasolato C, Pozzan T (1998) Capacitative Ca2+ entry is closely linked to the filling state of internal Ca2+ stores: a study using simultaneous measurements of ICRAC and intraluminal [Ca2+]. J. Cell Biol. 140:325-34. PubMed
  • Bezzi P, Carmignoto G, Pasti L, Vesce S, Rossi D, Rizzini BL, Pozzan T, Volterra A (1998) Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature 391:281-5. PubMed
  • Pinton P, Brini M, Bastianutto C, Tuft RA, Pozzan T, Rizzuto R (1998) New light on mitochondrial calcium. Biofactors 8:243-53. PubMed
  • Meldolesi J, Pozzan T (1998) The endoplasmic reticulum Ca2+ store: a view from the lumen. Trends Biochem. Sci. 23:10-4. PubMed
  • Fagioli M, Alcalay M, Tomassoni L, Ferrucci PF, Mencarelli A, Riganelli D, Grignani F, Pozzan T, Nicoletti I, Grignani F, Pelicci PG (1998) Cooperation between the RING + B1-B2 and coiled-coil domains of PML is necessary for its effects on cell survival. Oncogene 16:2905-13. PubMed
  • Rizzuto R, Pinton P, Carrington W, Fay FS, Fogarty KE, Lifshitz LM, Tuft RA, Pozzan T (1998) Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses Science 280:1763-6. PubMed
  • Robert V, De Giorgi F, Massimino ML, Cantini M, Pozzan T (1998) Direct monitoring of the calcium concentration in the sarcoplasmic and endoplasmic reticulum of skeletal muscle myotubes. J. Biol. Chem. 273:30372-8. PubMed
  • Meldolesi J, Pozzan T (1998) The heterogeneity of ER Ca2+ stores has a key role in nonmuscle cell signaling and function. J. Cell Biol. 142:1395-8. PubMed
  • Pinton P, Pozzan T, Rizzuto R (1998) The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum. EMBO J. 17:5298-308. PubMed
  • Landolfi B, Curci S, Debellis L, Pozzan T, Hofer AM (1998) Ca2+ homeostasis in the agonist-sensitive internal store: functional interactions between mitochondria and the ER measured In situ in intact cells. J. Cell Biol. 142:1235-43. PubMed
  • Scheenen WJ, Wollheim CB, Pozzan T, Fasolato C (1998) Ca2+ depletion from granules inhibits exocytosis. A study with insulin-secreting cells. J. Biol. Chem. 273:19002-8. PubMed
  • Carmignoto G, Pasti L, Pozzan T (1998) On the role of voltage-dependent calcium channels in calcium signaling of astrocytes in situ. J. Neurosci. 18:4637-45. PubMed
  • Brini M, De Giorgi F, Murgia M, Marsault R, Massimino ML, Cantini M, Rizzuto R, Pozzan T (1997) Subcellular analysis of Ca2+ homeostasis in primary cultures of skeletal muscle myotubes. Mol. Biol. Cell 8:129-43. PubMed
  • Pizzo P, Fasolato C, Pozzan T (1997) Dynamic properties of an inositol 1,4,5-trisphosphate- and thapsigargin-insensitive calcium pool in mammalian cell lines. J. Cell Biol. 136:355-66. PubMed
  • Marsault R, Murgia M, Pozzan T, Rizzuto R (1997) Domains of high Ca2+ beneath the plasma membrane of living A7r5 cells. EMBO J. 16:1575-81. PubMed
  • Maechler P, Kennedy ED, Pozzan T, Wollheim CB (1997) Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells. EMBO J. 16:3833-41. PubMed
  • Pozzan T (1997) Protein-protein interactions. Calcium turns turquoise into gold. Nature 388:834-5. PubMed
  • Pasti L, Volterra A, Pozzan T, Carmignoto G (1997) Intracellular calcium oscillations in astrocytes: a highly plastic, bidirectional form of communication between neurons and astrocytes in situ. J. Neurosci. 17:7817-30. PubMed
  • Montero M, Alvarez J, Scheenen WJ, Rizzuto R, Meldolesi J, Pozzan T (1997) Ca2+ homeostasis in the endoplasmic reticulum: coexistence of high and low [Ca2+] subcompartments in intact HeLa cells. J. Cell Biol. 139:601-11. PubMed
  • Rizzuto R, Brini M, De Giorgi F, Rossi R, Heim R, Tsien RY, Pozzan T (1996) Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo. Curr. Biol. 6:183-8. PubMed
  • Innocenti B, Pozzan T, Fasolato C (1996) Intracellular ADP modulates the Ca2+ release-activated Ca2+ current in a temperature- and Ca2+-dependent Way. J. Biol. Chem. 271:8582-7. PubMed
  • Lawrie AM, Rizzuto R, Pozzan T, Simpson AW (1996) A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells. J. Biol. Chem. 271:10753-9. PubMed
  • Rutter GA, Burnett P, Rizzuto R, Brini M, Murgia M, Pozzan T, Tavaré JM, Denton RM (1996) Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity. Proc. Natl. Acad. Sci. U.S.A. 93:5489-94. PubMed
  • Scheenen WJ, Makings LR, Gross LR, Pozzan T, Tsien RY (1996) Photodegradation of indo-1 and its effect on apparent Ca2+ concentrations. Chem. Biol. 3:765-74. PubMed
  • Kennedy ED, Rizzuto R, Theler JM, Pralong WF, Bastianutto C, Pozzan T, Wollheim CB (1996) Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cells. J. Clin. Invest. 98:2524-38. PubMed
  • Rizzuto R, Brini M, Bastianutto C, Marsault R, Pozzan T (1995) Photoprotein-mediated measurement of calcium ion concentration in mitochondria of living cells. Meth. Enzymol. 260:417-28. PubMed
  • Brini M, Marsault R, Bastianutto C, Alvarez J, Pozzan T, Rizzuto R (1995) Transfected aequorin in the measurement of cytosolic Ca2+ concentration ([Ca2+]c). A critical evaluation. J. Biol. Chem. 270:9896-903. PubMed
  • Rizzuto R, Brini M, Pizzo P, Murgia M, Pozzan T (1995) Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells. Curr. Biol. 5:635-42. PubMed
  • Pasti L, Pozzan T, Carmignoto G (1995) Long-lasting changes of calcium oscillations in astrocytes. A new form of glutamate-mediated plasticity. J. Biol. Chem. 270:15203-10. PubMed
  • Meldolesi J, Pozzan T (1995) IP3 receptors and secretory granules. Trends Neurosci. 18:340-1. PubMed
  • Bastianutto C, Clementi E, Codazzi F, Podini P, De Giorgi F, Rizzuto R, Meldolesi J, Pozzan T (1995) Overexpression of calreticulin increases the Ca2+ capacity of rapidly exchanging Ca2+ stores and reveals aspects of their lumenal microenvironment and function. J. Cell Biol. 130:847-55. PubMed
  • Montero M, Brini M, Marsault R, Alvarez J, Sitia R, Pozzan T, Rizzuto R (1995) Monitoring dynamic changes in free Ca2+ concentration in the endoplasmic reticulum of intact cells. EMBO J. 14:5467-75. PubMed
  • Rizzuto R, Brini M, Pozzan T (1994) Targeting recombinant aequorin to specific intracellular organelles. Methods Cell Biol. 40:339-58. PubMed
  • Fasolato C, Innocenti B, Pozzan T (1994) Receptor-activated Ca2+ influx: how many mechanisms for how many channels? Trends Pharmacol. Sci. 15:77-83. PubMed
  • Pozzan T, Rizzuto R, Volpe P, Meldolesi J (1994) Molecular and cellular physiology of intracellular calcium stores. Physiol. Rev. 74:595-636. PubMed
  • Rizzuto R, Bastianutto C, Brini M, Murgia M, Pozzan T (1994) Mitochondrial Ca2+ homeostasis in intact cells. J. Cell Biol. 126:1183-94. PubMed
  • Gamberucci A, Innocenti B, Fulceri R, Bànhegyi G, Giunti R, Pozzan T, Benedetti A (1994) Modulation of Ca2+ influx dependent on store depletion by intracellular adenine-guanine nucleotide levels. J. Biol. Chem. 269:23597-602. PubMed
  • Brini M, Marsault R, Bastianutto C, Pozzan T, Rizzuto R (1994) Nuclear targeting of aequorin. A new approach for measuring nuclear Ca2+ concentration in intact cells. Cell Calcium 16:259-68. PubMed
  • Lew DP, Jaconi M, Pozzan T (1993) Manipulation of cytosolic free calcium transients during exocytosis in intact human neutrophils. Meth. Enzymol. 221:157-73. PubMed
  • Rizzuto R, Brini M, Pozzan T (1993) Intracellular targeting of the photoprotein aequorin: a new approach for measuring, in living cells, Ca2+ concentrations in defined cellular compartments. Cytotechnology 11 Suppl 1:S44-6. PubMed
  • Rutter GA, Theler JM, Murgia M, Wollheim CB, Pozzan T, Rizzuto R (1993) Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion. J. Biol. Chem. 268:22385-90. PubMed
  • Rizzuto R, Brini M, Murgia M, Pozzan T (1993) Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science 262:744-7. PubMed
  • Brini M, Murgia M, Pasti L, Picard D, Pozzan T, Rizzuto R (1993) Nuclear Ca2+ concentration measured with specifically targeted recombinant aequorin. EMBO J. 12:4813-9. PubMed
  • Meldolesi J, Villa A, Volpe P, Pozzan T (1992) Cellular sites of IP3 action. Adv. Second Messenger Phosphoprotein Res. 26:187-208. PubMed
  • Clementi E, Scheer H, Zacchetti D, Fasolato C, Pozzan T, Meldolesi J (1992) Receptor-activated Ca2+ influx. Two independently regulated mechanisms of influx stimulation coexist in neurosecretory PC12 cells. J. Biol. Chem. 267:2164-72. PubMed
  • Villa A, Sharp AH, Racchetti G, Podini P, Bole DG, Dunn WA, Pozzan T, Snyder SH, Meldolesi J (1992) The endoplasmic reticulum of Purkinje neuron body and dendrites: molecular identity and specializations for Ca2+ transport. Neuroscience 49:467-77. PubMed
  • Rizzuto R, Simpson AW, Brini M, Pozzan T (1992) Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin Nature 358:325-7. PubMed
  • Treves S, Zorzato F, Pozzan T (1992) Identification of calreticulin isoforms in the central nervous system. Biochem. J. 287 ( Pt 2):579-81. PubMed
  • Pozzan T (1992) Two routes to neurotoxicity? Curr. Biol. 2:621-3. PubMed
  • Carpentier JL, Lew DP, Paccaud JP, Gil R, Iacopetta B, Kazatchkine M, Stendahl O, Pozzan T (1991) Internalization pathway of C3b receptors in human neutrophils and its transmodulation by chemoattractant receptors stimulation. Cell Regul. 2:41-55. PubMed
  • Milani D, Guidolin D, Facci L, Pozzan T, Buso M, Leon A, Skaper SD (1991) Excitatory amino acid-induced alterations of cytoplasmic free Ca2+ in individual cerebellar granule neurons: role in neurotoxicity. J. Neurosci. Res. 28:434-41. PubMed
  • Trevesø S, Zorzato F, Chiozzi P, Melandri P, Volpe P, Pozzan T (1991) Frog brain expresses a 60 KDa Ca2+ binding protein similar to mammalian calreticulin. Biochem. Biophys. Res. Commun. 175:444-50. PubMed
  • Villa A, Podini P, Clegg DO, Pozzan T, Meldolesi J (1991) Intracellular Ca2+ stores in chicken Purkinje neurons: differential distribution of the low affinity-high capacity Ca2+ binding protein, calsequestrin, of Ca2+ ATPase and of the ER lumenal protein, Bip. J. Cell Biol. 113:779-91. PubMed
  • Michelangeli F, Di Virgilio F, Villa A, Podini P, Meldolesi J, Pozzan T (1991) Identification, kinetic properties and intracellular localization of the (Ca(2+)-Mg2+)-ATPase from the intracellular stores of chicken cerebellum. Biochem. J. 275 ( Pt 3):555-61. PubMed
  • Meldolesi J, Clementi E, Fasolato C, Zacchetti D, Pozzan T (1991) Ca2+ influx following receptor activation. Trends Pharmacol. Sci. 12:289-92. PubMed
  • Zacchetti D, Clementi E, Fasolato C, Lorenzon P, Zottini M, Grohovaz F, Fumagalli G, Pozzan T, Meldolesi J (1991) Intracellular Ca2+ pools in PC12 cells. A unique, rapidly exchanging pool is sensitive to both inositol 1,4,5-trisphosphate and caffeine-ryanodine. J. Biol. Chem. 266:20152-8. PubMed
  • Fasolato C, Zottini M, Clementi E, Zacchetti D, Meldolesi J, Pozzan T (1991) Intracellular Ca2+ pools in PC12 cells. Three intracellular pools are distinguished by their turnover and mechanisms of Ca2+ accumulation, storage, and release. J. Biol. Chem. 266:20159-67. PubMed
  • Rubini M, Panozzo M, Selvatici R, Baricordi OR, Mazzilli MC, Pozzan T, Gandini E (1990) An anti-HLA class I monoclonal antibody alters the progression in the cell cycle of phytohemagglutinin-activated human T lymphocytes. Exp. Cell Res. 187:11-5. PubMed
  • Volpe P, Pozzan T, Meldolesi J (1990) Rapidly exchanging Ca2+Semin. Cell Biol. 1:297-304. PubMed
  • Satoh T, Ross CA, Villa A, Supattapone S, Pozzan T, Snyder SH, Meldolesi J (1990) The inositol 1,4,5,-trisphosphate receptor in cerebellar Purkinje cells: quantitative immunogold labeling reveals concentration in an ER subcompartment. J. Cell Biol. 111:615-24. PubMed
  • Pittet D, Di Virgilio F, Pozzan T, Monod A, Lew DP (1990) Correlation between plasma membrane potential and second messenger generation in the promyelocytic cell line HL-60. J. Biol. Chem. 265:14256-63. PubMed
  • Treves S, De Mattei M, Landfredi M, Villa A, Green NM, MacLennan DH, Meldolesi J, Pozzan T (1990) Calreticulin is a candidate for a calsequestrin-like function in Ca2(+)-storage compartments (calciosomes) of liver and brain. Biochem. J. 271:473-80. PubMed
  • Meldolesi J, Madeddu L, Pozzan T (1990) Intracellular Ca2+ storage organelles in non-muscle cells: heterogeneity and functional assignment. Biochim. Biophys. Acta 1055:130-40. PubMed
  • Pietrobon D, Di Virgilio F, Pozzan T (1990) Structural and functional aspects of calcium homeostasis in eukaryotic cells. Eur. J. Biochem. 193:599-622. PubMed
  • Fasolato C, Pizzo P, Pozzan T (1990) Receptor-mediated calcium influx in PC12 cells. ATP and bradykinin activate two independent pathways. J. Biol. Chem. 265:20351-5. PubMed
  • Tsien R, Pozzan T (1989) Measurement of cytosolic free Ca2+ with quin2. Meth. Enzymol. 172:230-62. PubMed
  • Krause KH, Pittet D, Volpe P, Pozzan T, Meldolesi J, Lew DP (1989) Calciosome, a sarcoplasmic reticulum-like organelle involved in intracellular Ca2+-handling by non-muscle cells: studies in human neutrophils and HL-60 cells. Cell Calcium 10:351-61. PubMed
  • Zanovello P, Rosato A, Bronte V, Cerundolo V, Treves S, Di Virgilio F, Pozzan T, Biasi G, Collavo D (1989) Interaction of lymphokine-activated killer cells with susceptible targets does not induce second messenger generation and cytolytic granule exocytosis. J. Exp. Med. 170:665-77. PubMed
  • Fasolato C, Pozzan T (1989) Effect of membrane potential on divalent cation transport catalyzed by the "electroneutral" ionophores A23187 and ionomycin. J. Biol. Chem. 264:19630-6. PubMed
  • Pozzan T, Volpe P, Zorzato F, Bravin M, Lew DP, Krause KH, Hashimoto S, Bruno B, Meldolesi J (1988) Immunocytological identification of the microsomal calcium store of nonmuscle cells. J. Cardiovasc. Pharmacol. 12 Suppl 5:S80-4. PubMed
  • Malgaroli A, Hashimoto S, Grohovaz F, Fumagalli G, Pozzan T, Meldolesi J (1988) Intracellular source(s) of [Ca2+]i transients in nonmuscle cells. Ann. N. Y. Acad. Sci. 551:159-66; discussion 1. PubMed
  • Volpe P, Krause KH, Hashimoto S, Zorzato F, Pozzan T, Meldolesi J, Lew DP (1988) "Calciosome", a cytoplasmic organelle: the inositol 1,4,5-trisphosphate-sensitive Ca2+ store of nonmuscle cells? Proc. Natl. Acad. Sci. U.S.A. 85:1091-5. PubMed
  • Cavallini G, Pozzan T, Selvatici R, Baricordi R, Mazzilli C, Gandini E (1988) Monoclonal antibodies against HLA class I antigens inhibit human lymphocyte proliferation but do not affect mitogen dependent second messenger generation. Biochem. Biophys. Res. Commun. 154:712-8. PubMed
  • Wollheim CB, Dunne MJ, Peter-Riesch B, Bruzzone R, Pozzan T, Petersen OH (1988) Activators of protein kinase C depolarize insulin-secreting cells by closing K+ channels. EMBO J. 7:2443-9. PubMed
  • Pozzan T, Volpe P, Zorzato F, Bravin M, Krause KH, Lew DP, Hashimoto S, Bruno B, Meldolesi J (1988) The Ins(1,4,5)P3-sensitive Ca2+ store of non-muscle cells: endoplasmic reticulum or calciosomes? J. Exp. Biol. 139:181-93. PubMed
  • Milani D, Volpe P, Pozzan T (1988) D-myo-inositol 1,4,5-trisphosphate phosphatase in skeletal muscle. Biochem. J. 254:525-9. PubMed
  • Hashimoto S, Bruno B, Lew DP, Pozzan T, Volpe P, Meldolesi J (1988) Immunocytochemistry of calciosomes in liver and pancreas. J. Cell Biol. 107:2523-31. PubMed
  • Fasolato C, Pandiella A, Meldolesi J, Pozzan T (1988) Generation of inositol phosphates, cytosolic Ca2+, and ionic fluxes in PC12 cells treated with bradykinin. J. Biol. Chem. 263:17350-9. PubMed
  • Meldolesi J, Gatti G, Ambrosini A, Pozzan T, Westhead EW (1988) Second-messenger control of catecholamine release from PC12 cells. Role of muscarinic receptors and nerve-growth-factor-induced cell differentiation. Biochem. J. 255:761-8. PubMed
  • Gatti G, Madeddu L, Pandiella A, Pozzan T, Meldolesi J (1988) Second-messenger generation in PC12 cells. Interactions between cyclic AMP and Ca2+ signals. Biochem. J. 255:753-60. PubMed
  • Meldolesi J, Volpe P, Pozzan T (1988) The intracellular distribution of calcium. Trends Neurosci. 11:449-52. PubMed
  • Volpe P, Zorzato F, Pozzan T, Salviati G, Di Virgilio F (1987) Measurement of calcium release from sarcoplasmic reticulum of skeletal muscle: effect of calcium and inositol 1,4,5-trisphosphate. Meth. Enzymol. 141:3-18. PubMed
  • Lew PD, Monod A, Waldvogel FA, Pozzan T (1987) Role of cytosolic free calcium and phospholipase C in leukotriene-B4-stimulated secretion in human neutrophils. Comparison with the chemotactic peptide formyl-methionyl-leucyl-phenylalanine. Eur. J. Biochem. 162:161-8. PubMed
  • Treves S, Di Virgilio F, Vaselli GM, Pozzan T (1987) Effect of cytochalasins on cytosolic-free calcium concentration and phosphoinositide metabolism in leukocytes. Exp. Cell Res. 168:285-98. PubMed
  • Di Virgilio F, Lew PD, Andersson T, Pozzan T (1987) Plasma membrane potential modulates chemotactic peptide-stimulated cytosolic free Ca2+ changes in human neutrophils. J. Biol. Chem. 262:4574-9. PubMed
  • Wanke E, Ferroni A, Malgaroli A, Ambrosini A, Pozzan T, Meldolesi J (1987) Activation of a muscarinic receptor selectively inhibits a rapidly inactivated Ca2+ current in rat sympathetic neurons. Proc. Natl. Acad. Sci. U.S.A. 84:4313-7. PubMed
  • Treves S, Di Virgilio F, Cerundolo V, Zanovello P, Collavo D, Pozzan T (1987) Calcium and inositolphosphates in the activation of T cell-mediated cytotoxicity. J. Exp. Med. 166:33-42. PubMed
  • Di Virgilio F, Milani D, Leon A, Meldolesi J, Pozzan T (1987) Voltage-dependent activation and inactivation of calcium channels in PC12 cells. Correlation with neurotransmitter release. J. Biol. Chem. 262:9189-95. PubMed
  • Pantaleo G, Olive D, Poggi A, Pozzan T, Moretta L, Moretta A (1987) Antibody-induced modulation of the CD3/T cell receptor complex causes T cell refractoriness by inhibiting the early metabolic steps involved in T cell activation. J. Exp. Med. 166:619-24. PubMed
  • Meldolesi J, Pozzan T (1987) Pathways of Ca2+ influx at the plasma membrane: voltage-, receptor-, and second messenger-operated channels. Exp. Cell Res. 171:271-83. PubMed
  • Malgaroli A, Vallar L, Elahi FR, Pozzan T, Spada A, Meldolesi J (1987) Dopamine inhibits cytosolic Ca2+ increases in rat lactotroph cells. Evidence of a dual mechanism of action. J. Biol. Chem. 262:13920-7. PubMed
  • Malgaroli A, Milani D, Meldolesi J, Pozzan T (1987) Fura-2 measurement of cytosolic free Ca2+ in monolayers and suspensions of various types of animal cells. J. Cell Biol. 105:2145-55. PubMed
  • Volpe P, Di Virgilio F, Pozzan T, Salviati G (1986) Role of inositol 1,4,5-trisphosphate in excitation-contraction coupling in skeletal muscle. FEBS Lett. 197:1-4. PubMed
  • Di Virgilio F, Salviati G, Pozzan T, Volpe P (1986) Is a guanine nucleotide-binding protein involved in excitation-contraction coupling in skeletal muscle? EMBO J. 5:259-62. PubMed
  • Di Virgilio F, Pozzan T, Wollheim CB, Vicentini LM, Meldolesi J (1986) Tumor promoter phorbol myristate acetate inhibits Ca2+ influx through voltage-gated Ca2+ channels in two secretory cell lines, PC12 and RINm5F. J. Biol. Chem. 261:32-5. PubMed
  • Capponi AM, Lew PD, Schlegel W, Pozzan T (1986) Use of intracellular calcium and membrane potential fluorescent indicators in neuroendocrine cells. Meth. Enzymol. 124:116-35. PubMed
  • Vicentini LM, Ambrosini A, Di Virgilio F, Meldolesi J, Pozzan T (1986) Activation of muscarinic receptors in PC12 cells. Correlation between cytosolic Ca2+ rise and phosphoinositide hydrolysis. Biochem. J. 234:555-62. PubMed
  • Pozzan T, Di Virgilio F, Vicentini LM, Meldolesi J (1986) Activation of muscarinic receptors in PC12 cells. Stimulation of Ca2+ influx and redistribution. Biochem. J. 234:547-53. PubMed
  • Bruzzone R, Pozzan T, Wollheim CB (1986) Caerulein and carbamoylcholine stimulate pancreatic amylase release at resting cytosolic free Ca2+. Biochem. J. 235:139-43. PubMed
  • Lew PD, Monod A, Waldvogel FA, Dewald B, Baggiolini M, Pozzan T (1986) Quantitative analysis of the cytosolic free calcium dependency of exocytosis from three subcellular compartments in intact human neutrophils. J. Cell Biol. 102:2197-204. PubMed
  • Iacopetta B, Carpentier JL, Pozzan T, Lew DP, Gorden P, Orci L (1986) Role of intracellular calcium and protein kinase C in the endocytosis of transferrin and insulin by HL60 cells. J. Cell Biol. 103:851-6. PubMed
  • Andersson T, Dahlgren C, Pozzan T, Stendahl O, Lew PD (1986) Characterization of fMet-Leu-Phe receptor-mediated Ca2+ influx across the plasma membrane of human neutrophils. Mol. Pharmacol. 30:437-43. PubMed
  • Vicentini LM, Di Virgilio F, Ambrosini A, Pozzan T, Meldolesi J (1985) Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells. Biochem. Biophys. Res. Commun. 127:310-7. PubMed
  • Arslan P, Di Virgilio F, Beltrame M, Tsien RY, Pozzan T (1985) Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+. J. Biol. Chem. 260:2719-27. PubMed
  • Vicentini LM, Ambrosini A, Di Virgilio F, Pozzan T, Meldolesi J (1985) Muscarinic receptor-induced phosphoinositide hydrolysis at resting cytosolic Ca2+ concentration in PC12 cells. J. Cell Biol. 100:1330-3. PubMed
  • Rink TJ, Pozzan T (1985) Using quin2 in cell suspensions. Cell Calcium 6:133-44. PubMed
  • Di Virgilio F, Vicentini LM, Treves S, Riz G, Pozzan T (1985) Inositol phosphate formation in fMet-Leu-Phe-stimulated human neutrophils does not require an increase in the cytosolic free Ca2+ concentration. Biochem. J. 229:361-7. PubMed
  • Madeddu L, Pozzan T, Robello M, Rolandi R, Hsiao TH, Meldolesi J (1985) Leptinotoxin-h action in synaptosomes, neurosecretory cells, and artificial membranes: stimulation of ion fluxes. J. Neurochem. 45:1708-18. PubMed
  • Meldolesi J, Huttner WB, Tsien RY, Pozzan T (1984) Free cytoplasmic Ca2+ and neurotransmitter release: studies on PC12 cells and synaptosomes exposed to alpha-latrotoxin. Proc. Natl. Acad. Sci. U.S.A. 81:620-4. PubMed
  • Lew PD, Wollheim C, Seger RA, Pozzan T (1984) Cytosolic free calcium changes induced by chemotactic peptide in neutrophils from patients with chronic granulomatous disease. Blood 63:231-3. PubMed
  • Tsien RY, Pozzan T, Rink TJ (1984) Calcium activities and fluxes inside small intact cells as measured with intracellularly trapped chelators. Adv Cyclic Nucleotide Protein Phosphorylation Res 17:535-41. PubMed
  • Arslan P, Corps AN, Hesketh TR, Metcalfe JC, Pozzan T (1984) cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes. Biochem. J. 217:419-25. PubMed
  • Lew PD, Dayer JM, Wollheim CB, Pozzan T (1984) Effect of leukotriene B4, prostaglandin E2 and arachidonic acid on cytosolic-free calcium in human neutrophils. FEBS Lett. 166:44-8. PubMed
  • Wollheim CB, Pozzan T (1984) Correlation between cytosolic free Ca2+ and insulin release in an insulin-secreting cell line. J. Biol. Chem. 259:2262-7. PubMed
  • Gennaro R, Pozzan T, Romeo D (1984) Monitoring of cytosolic free Ca2+ in C5a-stimulated neutrophils: loss of receptor-modulated Ca2+ stores and Ca2+ uptake in granule-free cytoplasts. Proc. Natl. Acad. Sci. U.S.A. 81:1416-20. PubMed
  • Lagast H, Pozzan T, Waldvogel FA, Lew PD (1984) Phorbol myristate acetate stimulates ATP-dependent calcium transport by the plasma membrane of neutrophils. J. Clin. Invest. 73:878-83. PubMed
  • Bernardi P, Paradisi V, Pozzan T, Azzone GF (1984) Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red. Biochemistry 23:1645-51. PubMed
  • Madeddu L, Meldolesi J, Pozzan T, Cardona Sanclemente LE, Bon C (1984) Alpha-latrotoxin and glycerotoxin differ in target specificity and in the mechanism of their neurotransmitter releasing action. Neuroscience 12:939-49. PubMed
  • Pozzan T, Gatti G, Dozio N, Vicentini LM, Meldolesi J (1984) Ca2+-dependent and -independent release of neurotransmitters from PC12 cells: a role for protein kinase C activation? J. Cell Biol. 99:628-38. PubMed
  • Lew PD, Wollheim CB, Waldvogel FA, Pozzan T (1984) Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils. J. Cell Biol. 99:1212-20. PubMed
  • Wollheim CB, Ullrich S, Pozzan T (1984) Glyceraldehyde, but not cyclic AMP-stimulated insulin release is preceded by a rise in cytosolic free Ca2+. FEBS Lett. 177:17-22. PubMed
  • Hesketh TR, Pozzan T, Smith GA, Metcalfe JC (1983) Limits to the early increase in free cytoplasmic calcium concentration during the mitogenic stimulation of lymphocytes. Biochem. J. 212:685-90. PubMed
  • Bragadin M, Pozzan T, Azzone GF (1983) The nature of the electron spin resonance signal during aerobic uptake of Mn2+ in mitochondria from rat liver. Eur. J. Biochem. 134:385-90. PubMed
  • Pozzan T, Lew DP, Wollheim CB, Tsien RY (1983) Is cytosolic ionized calcium regulating neutrophil activation? Science 221:1413-5. PubMed
  • Baumgarten E, Brand MD, Pozzan T (1983) Mechanism of activation of pyruvate dehydrogenase by mitogens in pig lymphocytes. Biochem. J. 216:359-67. PubMed
  • Arslan P, Miolo A, Montecucco C, Pozzan T (1982) Effect of ionophores on lymphocyte cellular metabolism. Adv. Exp. Med. Biol. 141:481-9. PubMed
  • Tsien RY, Pozzan T, Rink TJ (1982) T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes. Nature 295:68-71. PubMed
  • Corps AN, Metcalfe JC, Pozzan T (1982) Kinetic evidence for a common mechanism of capping on lymphocytes. Biochem. J. 204:229-37. PubMed
  • Pozzan T, Arslan P, Tsien RY, Rink TJ (1982) Anti-immunoglobulin, cytoplasmic free calcium, and capping in B lymphocytes. J. Cell Biol. 94:335-40. PubMed
  • Tsien RY, Pozzan T, Rink TJ (1982) Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator. J. Cell Biol. 94:325-34. PubMed
  • Rink TJ, Tsien RY, Pozzan T (1982) Cytoplasmic pH and free Mg2+ in lymphocytes. J. Cell Biol. 95:189-96. PubMed
  • Montecucco C, Ballardin S, Zaccolin GP, Pozzan T (1981) Effect of local anaesthetics on lymphocyte capping and energy metabolism. Biochem. Pharmacol. 30:2989-92. PubMed
  • Pozzan T, Corps AN, Hesketh TR, Metcalfe JC (1981) Mitogenic stimulation and the redistribution of concanavalin A receptors on lymphocytes. Exp. Cell Res. 134:399-408. PubMed
  • Arslan P, Montecucco C, Celi D, Pozzan T (1981) Effect of monovalent cation ionophores on lymphocyte cellular metabolism. Biochim. Biophys. Acta 643:177-81. PubMed
  • Montecucco C, Rink TJ, Pozzan T, Metcalfe JC (1980) Triggering of lymphocyte capping appears not to require changes in potential or ion fluxes across the plasma membrane. Biochim. Biophys. Acta 595:65-70. PubMed
  • Metcalfe JC, Pozzan T, Smith GA, Hesketh TR (1980) A calcium hypothesis for the control of cell growth. Biochem. Soc. Symp. 45:1-26. PubMed
  • Pozzan T, Corps AN, Montecucco C, Hesketh TR, Metcalfe JC (1980) Cap formation by various ligands on lymphocytes shows the same dependence on high cellular ATP levels. Biochim. Biophys. Acta 602:558-66. PubMed
  • Corps AN, Pozzan T, Hesketh TR, Metacalfe JC (1980) cis-Unsaturated fatty acids inhibit cap formation on lymphocytes by depleting cellular ATP. J. Biol. Chem. 255:10566-8. PubMed
  • Montecucco C, Pozzan T, Rink T (1979) Dicarbocyanine fluorescent probes of membrane potential block lymphocyte capping, deplete cellular ATP and inhibit respiration of isolated mitochondria. Biochim. Biophys. Acta 552:552-7. PubMed
  • Pozzan T, Di Virgilio F, Bragadin M, Miconi V, Azzone GF (1979) H+/site, charge/site, and ATP/site ratios in mitochondrial electron transport. Proc. Natl. Acad. Sci. U.S.A. 76:2123-7. PubMed
  • Bragadin M, Pozzan T, Azzone GF (1979) Activation energies and enthalpies during Ca2+ transport in rat liver mitochondria. FEBS Lett. 104:347-51. PubMed
  • Azzone GF, Pozzan T, Di Virgilio F (1979) H+/site, charge/site, and ATP/site ratios at coupling site III in mitochondrial electron transport. J. Biol. Chem. 254:10206-12. PubMed
  • Azzone GF, Pozzan T, Bragadin M, Miconi V (1979) Thermodynamics and kinetics of the H+ pump in mitochondrial electron transport. J. Biol. Chem. 254:10213-9. PubMed
  • Pozzan T, Miconi V, Di Virgilio F, Azzone GF (1979) H+/site, charge/site, and ATP/site ratios at coupling sites I and II in mitochondrial e- transport. J. Biol. Chem. 254:12000-5. PubMed
  • Bragadin M, Pozzan T, Azzone GF (1979) Kinetics of Ca2+ carrier in rat liver mitochondria. Biochemistry 18:5972-8. PubMed
  • Azzone GF, Pozzan T, Massari S (1978) Proton electrochemical gradient and phosphate potential in mitochondria. Biochim. Biophys. Acta 501:307-16. PubMed
  • Azzone GF, Pozzan T, Massari S, Bragadin M (1978) Proton electrochemical gradient and rate of controlled respiration in mitochondria. Biochim. Biophys. Acta 501:296-306. PubMed
  • Azzone GF, Pozzan T, Viola E, Arslan P (1978) Proton electrochemical gradient and phosphate potential in submitochondrial particles. Biochim. Biophys. Acta 501:317-29. PubMed
  • Azzone GF, Pozzan T, Massari S, Bragadin M, Dell'Antone P (1977) H+/site ratio and steady state distribution of divalent cations in mitochondria. FEBS Lett. 78:21-4. PubMed
  • Azzone GF, Pozzan T, Bragadin M (1977) Proton pump and membrane potential in liver mitochondria. Biochem. Soc. Trans. 5:487-91. PubMed
  • Azzone GF, Bragadin M, Pozzan T, Antone PD (1977) Proton electrochemical potential in steady state rat liver mitochondria. Biochim. Biophys. Acta 459:96-109. PubMed
  • Azzone GF, Massari S, Pozzan T (1977) The generation of the proton electrochemical potential and its role in energy transduction. Mol. Cell. Biochem. 17:101-12. PubMed
  • Pozzan T, Bragadin M, Azzone GF (1977) Disequilibrium between steady-state Ca2+ accumulation ratio and membrane potential in mitochondria. Pathway and role of Ca2+ efflux. Biochemistry 16:5618-25. PubMed
  • Pozzan T, Bragadin M, Azzone GF (1976) The effect of endogenous phosphate on the H+/Mn2+ ratio and the state of Mn2+ in the mitochondrial matrix. Eur. J. Biochem. 71:93-9. PubMed
  • Pozzan T, Azzone GF (1976) The coupling of electrical ion fluxes in rat liver mitochondria. FEBS Lett. 72:62-6. PubMed
  • Massari S, Pozzan T (1976) The accumulation ratio of K+, Na+, Ca2+ and tetrapropylammonium in steady-state Mitochondria. Arch. Biochem. Biophys. 173:332-40. PubMed
  • Azzone GF, Massari S, Pozzan T (1976) Mechanism of active shrinkage in mitochondria. I. Coupling between weak electrolyte fluxes. Biochim. Biophys. Acta 423:15-26. PubMed
  • Azzone GF, Massair S, Pozzan T (1976) Mechanism of active shrinkage in mitochondria. II. Coupling between strong electrolyte fluxes. Biochim. Biophys. Acta 423:27-41. PubMed
  • Massari S, Pozzan T (1976) The interaction of organic cations with the mitochondrial membrane. Experientia 32:868-9. PubMed
  • Bragadin M, Dell'antone P, Pozzan T, Volpato O, Azzone GF (1975) ESR determination of Mn++ uptake and binding in mitochondria FEBS Lett. 60:354-8. PubMed

 

Hallmark publications

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Giacomello M, Drago I, Bortolozzi M, Scorzeto M, Gianelle A, Pizzo P, Pozzan T (2010) Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels. Mol. Cell 38:280-90.
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Lissandron V, Podini P, Pizzo P, Pozzan T (2010) Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment Proc. Natl. Acad. Sci. U.S.A. 107:9198-203.
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Rizzuto R, Pinton P, Carrington W, Fay FS, Fogarty KE, Lifshitz LM, Tuft RA, Pozzan T (1998) Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses Science 280:1763-6.
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Rizzuto R, Simpson AW, Brini M, Pozzan T (1992) Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin Nature 358:325-7.
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Tsien RY, Pozzan T, Rink TJ (1982) T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes. Nature 295:68-71.
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