Welcome to the Pozzan Lab website. Our lab is located in the Vallisneri Biology Complex, a multi-department research centre of the University of Padua; we are part of the Department of Biomedical Sciences.
Historically, our lab has been interested in calcium (Ca2+), its homeostasis, and its role in cell signalling, both in health and disease.
One of the major topics of the lab over the last years has been the development and use of organelle targeted GFP-based fluorescent indicators for monitoring second messenger levels in living cells. In the last years, novel Ca2+ indicators for peroxisomes, Golgi apparatus, and mitochondria have been generated and characterized. These novel tools have allowed for the first time to address the study of Ca2+ homeostasis in subcellular compartments for which until now only indirect information was available. In addition to Ca2+, much of the interest of our group is concentrated on cAMP probes. In this context, novel tools—again targeted to subcellular regions (plasma membrane, mitochondria, nucleus)—have been generated or are under development. These methodologies are instrumental for addressing with novel approaches the role of second messenger heterogeneity in physiological and pathological conditions.
The Research section of this website contains additional information regarding current projects, as well as a comprehensive list of research papers that reflect our scientific activity.
More examples can be found in the Research section.
Giacomello M, Drago I, Bortolozzi M, Scorzeto M, Gianelle A, Pizzo P, Pozzan T (2010) Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels. Mol. Cell 38:280-90.
A full list of our publications can be found here.
Scheduled at the Vallisneri, the VIMM,
and nearby departments.